The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration
The SDF-1/CXCR4 chemokine axis in uveal melanoma cell proliferation and migration
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SDF-1/CXCR4趋化因子轴在葡萄膜黑色素瘤细胞增殖和迁移中的作用
DOI：
10.1007/s13277-015-4259-4
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发表时间：
2016-03-01
期刊：
影响因子：
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通讯作者：
Ge, Shengfang
中科院分区：
文献类型：
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作者：
Bi, Jianjun;Li, Peng;Ge, Shengfang
基质细胞衍生因子1（SDF-1）/趋化因子受体4（CXCR 4）趋化因子轴在肿瘤迁移中起关键作用。在这里，我们分析了葡萄膜黑色素瘤（UM）增殖和迁移的轴，并研究了CXCR 4的化学抑制剂AMD 3100对UM的影响。我们发现，CXCR 4在所有五个UM细胞系以及视网膜色素上皮细胞系ARPE-19细胞中表达，而CXCR 7仅在OM 290和VUP细胞系中检测到。SDF-1促进OCM-1和OCM 431细胞系的增殖和迁移，而AMD 3100削弱了这一功能。综上所述，我们的结果表明SDF-1/CXCR 4趋化因子轴在UM细胞增殖和迁移中起关键作用，并且AMD 3100可以减轻这种功能，这可能为UM治疗提供线索。
The stromal-cell-derived factor 1 (SDF-1)/chemokine receptor 4 (CXCR4) chemokine axis plays a key role in tumor migration. Here, we analyzed the axis in uveal melanoma (UM) proliferation and migration and investigated the effect of a chemical inhibitor of CXCR4, AMD3100, on UM. We found that CXCR4 was expressed in all five UM cell lines tested as well as the retinal pigment epithelium cell line ARPE-19 cells, while CXCR7 was only detected in OM290 and VUP cell lines. SDF-1 promotes the proliferation and migration of OCM-1 and OCM431 cell lines, while AMD3100 weakens this function. Taken together, our results show that the SDF-1/CXCR4 chemokine axis plays a key role in UM cell proliferation and migration and that AMD3100 can alleviate this function, which may offer a hint for UM treatment.