Untangling the Effect of Head Acceleration on Brain Responses to Blast Waves.
Untangling the Effect of Head Acceleration on Brain Responses to Blast Waves.
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解开头部加速度对大脑对冲击波反应的影响。
DOI：
10.1115/1.4031765
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
Reifman,Jaques
中科院分区：
文献类型：
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作者：
Mao,Haojie;Unnikrishnan,Ginu;Rakesh,Vineet;Reifman,Jaques
冲击波的传播、颅骨弯曲、空化和头部加速度等多种致伤机制已被提出来解释冲击波致创伤性脑损伤（bTBI）。对这些机制中的每一个的单独贡献的准确、定量描述对于制定针对bTBI的预防策略可能是必要的。然而，迄今为止，尽管有许多bTBI的实验和计算研究，这个问题仍然难以捉摸。在这项研究中，使用一个二维（2D）大鼠头部模型，我们量化的头部加速度的脑组织的生物力学响应时，暴露于冲击波在冲击管的贡献。我们比较了能够模拟所有机制的2D大鼠头部模型（即，所有效应模型）和仅加速度模型。从我们的模拟中，我们确定头部加速度在政变区域贡献了36-45%的最大脑压，对中间区域的压力影响可以忽略不计，并且是造成对流政变区域低压的原因。我们的研究结果还表明，目前测量靠近大脑中心的大鼠脑压的做法只能记录在政变地区观察到的最大压力的三分之二。因此，为了准确地捕捉实验中的加速度效应，我们建议在耦合区域附近放置压力传感器，特别是在使用不同的实验设置研究加速度机制时。
Multiple injury-causing mechanisms, such as wave propagation, skull flexure, cavitation, and head acceleration, have been proposed to explain blast-induced traumatic brain injury (bTBI). An accurate, quantitative description of the individual contribution of each of these mechanisms may be necessary to develop preventive strategies against bTBI. However, to date, despite numerous experimental and computational studies of bTBI, this question remains elusive. In this study, using a two-dimensional (2D) rat head model, we quantified the contribution of head acceleration to the biomechanical response of brain tissues when exposed to blast waves in a shock tube. We compared brain pressure at the coup, middle, and contre-coup regions between a 2D rat head model capable of simulating all mechanisms (i.e., the all-effects model) and an acceleration-only model. From our simulations, we determined that head acceleration contributed 36–45% of the maximum brain pressure at the coup region, had a negligible effect on the pressure at the middle region, and was responsible for the low pressure at the contre-coup region. Our findings also demonstrate that the current practice of measuring rat brain pressures close to the center of the brain would record only two-thirds of the maximum pressure observed at the coup region. Therefore, to accurately capture the effects of acceleration in experiments, we recommend placing a pressure sensor near the coup region, especially when investigating the acceleration mechanism using different experimental setups.