Different members of the fibroblast growth factor receptor family are specific to distinct cell types in the developing chicken embryo.
Different members of the fibroblast growth factor receptor family are specific to distinct cell types in the developing chicken embryo.
复制标题
DOI：
10.1006/dbio.1993.1011
复制
发表时间：
1993
影响因子：
2.7
通讯作者：
G. Patstone;E. Pasquale;P. Maher
中科院分区：
文献类型：
--
作者：
G. Patstone;E. Pasquale;P. Maher
Single-stranded RNA probes for the three chicken fibroblast growth factor (FGF) receptors, cek-1, cek-2, and cek-3, in conjunction with in situ hybridization were used to characterize the distribution of the corresponding mRNAs in the developing chicken embryo. Cek-1 was expressed diffusely in most tissues examined, whereas the expression of cek-2 and cek-3 was more restricted. The highest levels of FGF receptor expression were seen in the developing bones; in skeletal, cardiac, and smooth muscle; and in some areas of the brain. Although all three receptors were expressed in a number of the same tissues, the expression of each receptor within a given tissue was generally specific for different cell types. In addition, the distribution of each of these receptors did not correlate with the previously characterized distributions of individual FGFs. These results suggest that the members of the FGF receptor family may represent cell-type-specific receptors rather than ligand-specific receptors. Thus, the interaction between a growth factor of the FGF family and a given FGF receptor is likely to be controlled to a large extent by spatial constraints, rather than exclusively by high binding affinities.
