Ketogenic diet activates protective γδ T cell responses against influenza virus infection
Ketogenic diet activates protective γδ T cell responses against influenza virus infection
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DOI：
10.1126/sciimmunol.aav2026
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发表时间：
2019-11-01
影响因子：
24.8
通讯作者：
Iwasaki, Akiko
中科院分区：
文献类型：
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作者：
Goldberg, Emily L.;Molony, Ryan D.;Iwasaki, Akiko
甲型流感病毒（IAV）感染相关的发病率和死亡率是一个关键的全球卫生保健问题，因此有必要确定能够降低IAV感染严重程度的新疗法。在这项研究中，我们发现低碳水化合物、高脂肪生酮饮食（KD）可以保护小鼠免受致命的IAV感染和疾病。KD喂养导致肺中γ δ T细胞的扩增，从而改善屏障功能，从而增强抗病毒抗性。这些保护性γ δ T细胞的扩张需要对生酮饮食进行代谢适应，因为无论是给小鼠喂食高脂肪、高碳水化合物的饮食，还是提供绕过肝脏生酮的化学酮体底物，都不能保护小鼠免受感染。因此，kd介导的免疫代谢整合是预防或减轻流感疾病的可行途径。
Influenza A virus (IAV) infection-associated morbidity and mortality are a key global health care concern, necessitating the identification of new therapies capable of reducing the severity of IAV infections. In this study, we show that the consumption of a low-carbohydrate, high-fat ketogenic diet (KD) protects mice from lethal IAV infection and disease. KD feeding resulted in an expansion of gamma delta T cells in the lung that improved barrier functions, thereby enhancing antiviral resistance. Expansion of these protective gamma delta T cells required metabolic adaptation to a ketogenic diet because neither feeding mice a high-fat, high-carbohydrate diet nor providing chemical ketone body substrate that bypasses hepatic ketogenesis protected against infection. Therefore, KD-mediated immune-metabolic integration represents a viable avenue toward preventing or alleviating influenza disease.