Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable Alzheimer's disease
Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable Alzheimer's disease
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DOI：
10.1007/s10072-011-0889-5
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发表时间：
2012-10-01
影响因子：
3.3
通讯作者：
Perani, D.
中科院分区：
文献类型：
--
作者：
Garibotto, V.;Borroni, B.;Perani, D.
根据储备假说，高教育/职业成就可以调节阿尔茨海默病（AD）的临床表现。载脂蛋白E（ApoE）等位基因对AD储备机制的影响尚未评估。这项欧洲多中心研究的目的是评估储备和ApoE基因型在早期可能AD中的代谢相关性。51例AD受试者，27例携带者和24例非携带者，接受了FDG-PET脑成像。我们使用SPM 2中实现的一般线性模型来测试储备指数的线性相关性，考虑教育和职业水平，大脑葡萄糖代谢，控制人口统计学变量（年龄和性别）和认知表现。我们发现储备指数之间的负相关，占教育/职业水平，代谢在后扣带皮层和楔前叶在两个104携带者和非携带者，组之间没有显着差异。我们发现，教育和职业作为代理储备在ApoE 144携带者，补偿不利的遗传背景，我们还表明，补偿的程度并没有显着不同的ApoE 144状态。
According to the reserve hypothesis, a high educational/occupational attainment can modulate Alzheimer's disease (AD) clinical expression. The impact of the Apolipoprotein E (ApoE) epsilon 4 allele on the reserve mechanism in AD has not been assessed. Aim of this European multicenter study was to evaluate the metabolic correlates of reserve and ApoE genotype in early probable AD. 51 AD subjects, 27 epsilon 4 carriers, and 24 noncarriers, underwent FDG-PET brain imaging. We used the general linear model as implemented in SPM2 to test for the linear correlation of a reserve index, accounting for both educational and occupational level, with brain glucose metabolism, controlling for demographic variables (age and gender) and for cognitive performance. We found an inverse correlation between a reserve index, accounting for educational/occupational level, and metabolism in the posterior cingulate cortex and precuneus in both epsilon 4 carriers and noncarriers, and no significant difference between the groups. We show that education and occupation act as proxies for reserve in epsilon 4 carriers, compensating for an unfavorable genetic background; we also show that the degree of compensation does not differ significantly by ApoE epsilon 4 status.