THE ANALYSIS OF DRUG-INDUCED TREMOR IN MICE
THE ANALYSIS OF DRUG-INDUCED TREMOR IN MICE
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DOI：
10.1111/j.1476-5381.1959.tb00255.x
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发表时间：
1959-01-01
期刊：
影响因子：
--
通讯作者：
TAYLOR, NRW
中科院分区：
文献类型：
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作者：
AHMED, A;TAYLOR, NRW
描述了一种用于记录药物诱导的小鼠震颤的方法;将动物放置在连接到留声机拾取器的轻塑料盒中。在示波器上记录拾取器的输出。定性和定量评价的记录。几种药物产生的模式进行了讨论，参考他们的其他药理学特性。骆驼蓬碱和骆驼蓬碱产生正弦型震颤模式，与1，4-双（1-吡咯烷基）-2-1丁炔（震颤素）非常相似，但不伴有与后一种化合物相关的中枢副交感神经刺激。氨基三苯丙醇产生的震颤模式在振幅和频率上完全不规则，类似于正常运动的夸张。麦角酰二乙胺（LSD）的表现相似，但程度较轻，震颤指数较低。
A method for recording drug-induced tremor in mice is described; the animals are placed in a light plastic box attached to a gramophone pick-up. The output of the pick-up was recorded on an oscilloscope. Qualitative and quantitative evaluation of the records is described. The patterns produced by several drugs are discussed with reference to their other pharmacological properties. Harmine and harmaline gave a sinusoidal type of tremor pattern closely resembling that of 1,4-bis(l -pyrrolidinyl) -2-1 butyne (Tremorine), but it was not accompanied by the central para-sympathetic stimulation associated with the latter compound. Aminotri -phenylpropanol produced a tremor pattern completely irregular in amplitude and frequency, resembling an exaggeration of normal movement. Lysergic acid diethylamide (LSD) gave a similar but less severe pattern and the tremor index was lower.