Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta.
Docosahexaenoic acid (22:6n3)-induced relaxation of the rat aorta.
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二十二碳六烯酸 (22:6n3) 诱导大鼠主动脉舒张。
DOI：
10.1016/0014-2999(90)90644-l
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发表时间：
1990
影响因子：
5
通讯作者：
N. Salem
中科院分区：
文献类型：
--
作者：
M. Engler;J. Karanian;N. Salem
饮食中摄入含有二十碳五烯酸和二十二碳六烯酸的鱼和鱼油补充剂，与心血管系统的有利变化有关，如降低血压。因此，我们观察了二十二碳六烯酸(22：6n3)对大鼠主动脉平滑肌等长张力的影响。在非预收缩的血管中，22：6N3可引起浓度依赖的(1-127μM)松弛(6-30%)。浓度依赖的二十二碳六烯酸(1-44μM)可逆转苯肾上腺素(7-43%)和U44069(8-52%)引起的大鼠主动脉环收缩。这些结果表明，22：6N3对大鼠主动脉的松弛作用是浓度依赖的，而不是收缩激动剂所特有的。
Dietary consumption of fish and fish oil supplements, containing eicosapentaenoic acid and docosahexaenoic acid, has been associated with favorable alterations in the cardiovascular system, such as, a reduction in blood pressure. Therefore, the effects of docosahexaenoic acid (22:6n3) on isometric tension of rat aortic smooth muscle were investigated. A concentration-dependent (1–127 μM) relaxation (6–30%) was induced by 22:6n3 in non-precontracted vessels. Docosaehexaenoic acid, concentration dependently (1–44 μM) reversed contractions of rat aortic rings induced by phenylephrine (7–43%) and by U44069 (8–52%). These results indicate that the relaxant effects produced by 22 : 6n3 in the rat aorta are concentration-dependent and not specific to the contractile agonist.