Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds
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DOI：
10.1158/0008-5472.can-03-3823
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发表时间：
2004-04-01
期刊：
影响因子：
11.2
通讯作者：
Hruban, RH
中科院分区：
文献类型：
--
作者：
Klein, AP;Brune, KA;Hruban, RH
有胰腺癌家族史的个体患胰腺癌的风险增加。这种风险的量化为癌症风险咨询和早期胰腺癌筛查提供了合理的基础。在一项基于登记的前瞻性研究中，我们估计了有胰腺癌家族史的个体患胰腺癌的风险。通过比较观察到的胰腺癌事件数与使用监测、流行病学和最终结果（SEER）率预期的胰腺癌事件数，计算标准化发病率。家族性胰腺癌（FPC）家族性胰腺癌（FPC家族性胰腺癌）家族性胰腺癌（SPC家族性胰腺癌）家族性胰腺癌在来自838个激酶的5，179个个体中发生了19例胰腺癌事件（基线时，370例FPC激酶和468例SPC激酶）。在这5，179名患者中，3，957人至少有一名一级亲属患有胰腺癌，并提供了10，538人年的随访。在该组中，FPC激酶成员的胰腺癌符合预期率显著升高[9.0; 95%置信区间（CI），4.5-16.1]，但SPC激酶成员的胰腺癌符合预期率未显著升高[1.8; 95% CI，0.22-6.4）。在有三个（32.0; 95% CI，10.2-74.7）、两个（6.4; CI，1.8-16.4）或一个（4.6; CI，0.5-16.4）一级亲属患有胰腺癌的个体中，FPC激酶的这种风险升高。在369名配偶和其他基因无关的亲属中，风险没有增加。吸烟者的风险高于不吸烟者。有胰腺癌家族史的个体患胰腺癌的风险显著增加。
Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic cancer. Quantification of this risk provides a rational basis for cancer risk counseling and for screening for early pancreatic cancer. In a prospective registry-based study, we estimated the risk of pancreatic cancer in individuals with a family history of pancreatic cancer. Standardized incidence ratios were calculated by comparing the number of incident pancreatic cancers observed with those expected using Surveillance, Epidemiology and End Results (SEER) rates. Familial pancreatic cancer (FPC) kindreds were defined as kindreds having at least one pair of first-degree relatives with pancreatic cancer, and sporadic pancreatic cancer (SPC) kindreds as families without such an affected pair. Nineteen incident pancreatic cancers developed among 5,179 individuals from 838 kindreds (at baseline, 370 FPC kindreds and 468 SPC kindreds). Of these 5,179 individuals, 3,957 had at least one first-degree relative with pancreatic cancer and contributed 10,538 person-years of follow-up. In this group, the observed-to-expected rate of pancreatic cancer was significantly elevated in members of FPC kindreds [9.0; 95% confidence interval (CI), 4.5-16.1], but not in the SPC kindreds (1.8; 95% CI., 0.22-6.4). This risk in FPC kindreds was elevated in individuals with three (32.0; 95% CI, 10.2-74.7), two (6.4; CI, 1.8-16.4), or one (4.6; CI, 0.5-16.4) first-degree relative(s) with pancreatic cancer. Risk was not increased among 369 spouses and other genetically unrelated relatives. Risk was higher in smokers than in nonsmokers. Individuals with a strong family history of pancreatic cancer have a significantly increased risk of developing pancreatic cancer.