Vulnerability of the gradually elongated nerve to compression injury.
Vulnerability of the gradually elongated nerve to compression injury.
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DOI：
10.1142/s0218810401000400
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发表时间：
2001-07-01
期刊：
影响因子：
--
通讯作者：
Tanaka, S
中科院分区：
文献类型：
--
作者：
Ikeda, K;Yokoyama, M;Tanaka, S
本研究的目的是阐明逐渐拉长的周围神经的脆弱性。兔的坐骨神经以2.0mm/天和4.0mm/天的速度逐渐拉长至30mm。伸长后，立即暴露坐骨神经，并以不同的力（15、30和60 g/0.1 cm(2)）压缩30分钟。伸长和压缩后，压缩后2、4和8周，对各组进行电生理学和组织学评估——-15 g/0.1 cm(2)对对照组无损伤，2.0 mm/天组出现神经失用，4.0 mm/天组出现轴索断裂； 30 g/0.1 cm(2) 导致对照组神经失用，2.0 mm/天组导致轴索断裂； 60 g/0.1 cm(2) 导致对照组轴突断裂，2.0 mm/天组轴突断裂缓慢恢复。这项研究表明，虽然轻微的压迫不会对完整的神经造成神经损伤，但有时会对逐渐拉长的神经造成严重损伤。
The purpose of this study is to clarify the vulnerability of the gradually elongated peripheral nerve. Rabbit's sciatic nerves were gradually elongated to 30 mm at the rate of 2.0 mm/day and 4.0 mm/day. Immediately after elongation, the sciatic nerve was exposed and compressed for 30 minutes at various forces, 15, 30 and 60 g/0.1 cm(2). Immediately after elongation and compression, 2, 4 and 8 weeks after compression, each group was electrophysiologically and histologically estimated--15 g/0.1 cm(2) caused no damage to the control group, neurapraxia to the 2.0 mm/day group, and axonotmesis to the 4.0 mm/day group; 30 g/0.1 cm(2) caused neurapraxia to the control group and axonotmesis to the 2.0 mm/day group; 60 g/0.1 cm(2) caused axonotmesis to the control group and slowly recovered axonotmesis to the 2.0 mm/day group. This study shows that though mild compression, does not cause nerve injury to the intact nerve, it can sometimes cause severe damage to the gradual elongated nerve.