Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force.
Subthalamic nucleus beta and gamma activity is modulated depending on the level of imagined grip force.
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DOI：
10.1016/j.expneurol.2017.03.015
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发表时间：
2017-07
影响因子：
5.3
通讯作者：
Tan H
中科院分区：
文献类型：
--
作者：
Fischer P;Pogosyan A;Cheeran B;Green AL;Aziz TZ;Hyam J;Little S;Foltynie T;Limousin P;Zrinzo L;Hariz M;Samuel M;Ashkan K;Brown P;Tan H
运动想象涉及类似于由真实的运动激活的皮层网络，但基底神经节被招募的程度尚不清楚。在丘脑底核（subthalamic nucleus，简称STN）中的γ和β振荡随着持续肌肉活动的努力而变化。我们记录了帕金森病患者的局部场电位，并研究了在三种不同的“力”下想象抓握时是否可以观察到类似的变化。我们发现，只有在两个较强的力量水平下，想象的抓握才能显著降低β活动。此外，伽马功率随着想象力的增加而显著缩放。因此，结合起来，这两个光谱特征即使在没有感觉反馈的情况下也可以提供关于假想抓握的预期力的信息。在想象运动过程中两个频段的调制可以解释运动想象改善运动表现的康复益处。研究结果还表明，脑-机接口可能会提供有用的信息。我们测试了丘脑底核参与运动想象的程度。在三个力水平下的真实的夹持过程中，β和γ活性被缩放。在想象抓握过程中也观察到了力依赖性调制。神经反馈可以支持运动训练或脑机接口。
Motor imagery involves cortical networks similar to those activated by real movements, but the extent to which the basal ganglia are recruited is not yet clear. Gamma and beta oscillations in the subthalamic nucleus (STN) vary with the effort of sustained muscle activity. We recorded local field potentials in Parkinson's disease patients and investigated if similar changes can be observed during imagined gripping at three different ‘forces’. We found that beta activity decreased significantly only for imagined grips at the two stronger force levels. Additionally, gamma power significantly scaled with increasing imagined force. Thus, in combination, these two spectral features can provide information about the intended force of an imaginary grip even in the absence of sensory feedback. Modulations in the two frequency bands during imaginary movement may explain the rehabilitating benefit of motor imagery to improve motor performance. The results also suggest that STN LFPs may provide useful information for brain-machine interfaces. We tested to which extent the subthalamic nucleus is involved in motor imagery. During real gripping at three force levels beta and gamma activity is scaled. Force-dependent modulation also was observed during imagined gripping. STN neuro-feedback may support motor training or brain-machine interfaces.