The effect of rate of weight loss on long-term weight regain in adults with overweight and obesity

The effect of rate of weight loss on long-term weight regain in adults with overweight and obesity
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DOI：
10.1002/oby.21346
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发表时间：
2016-02-01
期刊：
OBESITY
影响因子：
6.9
通讯作者：
van Baak, Marleen A.
van Baak, Marleen A.
中科院分区：
医学2区
文献类型：
--
作者：
Vink, Roel G.;Roumans, Nadia J. T.;van Baak, Marleen A.

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目的探讨体重减轻率与总体重减轻率相近对超重和肥胖人群体重恢复的影响。方法57名参与者（BMI: 28-35 kg/m(2)）接受饮食干预（DI）。他们被随机分配到低热量饮食（LCD； 1250千卡/天）12周（缓慢减肥）或极低热量饮食（VLCD； 500千卡/天）5周（快速减肥）（减肥（WL）期），然后是4周的体重稳定（WS）期和9个月的随访。在研究开始时和研究结束后测定体重和体成分（BodPod）。结果两组术后体重变化相似（LCD: -8.2 kg, VLCD: -9.0 kg， P=0.24）。各组随访后体重恢复无显著差异（LCD: 4.2 kg, VLCD: 4.5 kg， P=0.73）。与lcd组相比，vlcd组在DI后的无脂质量损失率（%FFML）更高（分别为8.8%和1.3%，P=0.034），并且与整个组随访期间的体重恢复相关（r=0.325， P=0.018）。结论本研究表明，在总减重相似的情况下，减重速度对体重恢复没有影响。然而，DI后的FFML与体重恢复有关。
ObjectiveTo investigate the effect of rate of weight loss, with similar total weight loss, on weight regain in individuals with overweight and obesity.MethodsFifty-seven participants (BMI: 28-35 kg/m(2)) underwent a dietary intervention (DI). They were randomized to a low-calorie diet (LCD; 1250 kcal/day) for 12 weeks (slow weight loss) or a very-low-calorie diet (VLCD; 500 kcal/day) for 5 weeks (rapid weight loss) (weight loss (WL) period) followed by a 4-week weight-stable (WS) period and 9 months follow-up. Body weight and body composition (BodPod) were determined at study start and after each period.ResultsWeight change was similar in both groups after WL (LCD: -8.2 kg and VLCD: -9.0 kg, P=0.24). Weight regain after follow-up was not significantly different between groups (LCD: 4.2 kg and VLCD: 4.5 kg, P=0.73). Percentage fat-free mass loss (%FFML) was higher in the VLCD-group compared to the LCD-group after DI (8.8% and 1.3%, respectively, P=0.034) and was associated with weight regain during follow-up in the whole group (r=0.325, P=0.018).ConclusionsThe present study showed that, with similar total weight loss, rate of weight loss did not affect weight regain. However, %FFML after DI was associated with weight regain.