Synergistic effects of citric acid - sodium alginate on physicochemical properties of alpha-tricalcium phosphate bone cement
Synergistic effects of citric acid - sodium alginate on physicochemical properties of alpha-tricalcium phosphate bone cement
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柠檬酸-海藻酸钠对α-磷酸三钙骨水泥理化性能的协同作用
DOI：
10.1016/j.ceramint.2018.10.124
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发表时间：
2019
影响因子：
5.2
通讯作者：
Zhou Changren
中科院分区：
文献类型：
--
作者：
Shi Haishan;Zhang Wenqian;Liu Xu;Zeng Shenghui;Yu Tao;Zhou Changren
磷酸钙骨水泥是目前应用最广泛的骨替代材料之一，但其物理化学性能较差，严重限制了其临床应用。将钙结合剂柠檬酸（CA）和海藻酸钠（SA）联合引入α-磷酸三钙（α-TCP）骨水泥中，以改善其理化性能。进一步研究了CA和SA对水泥的物相、形貌、变形、操作性和力学性能的影响。两种试剂的共存显著缩短了凝固时间，同时以CA含量依赖的方式改善了α-TCP骨水泥的抗冲刷能力、可注射性和机械强度。SA-CA凝胶网络在骨水泥基质中的快速形成增强了糊剂的流动性，具有较强的内聚作用，这有利于临床注射。在此，CA和SA的结合应该为开发具有良好理化性质的可注射骨水泥铺平道路，用于许多临床骨科应用。
Calcium phosphate bone cement is one of the most widely used bone substitutes, but its clinical use is still critically limited by its poor physicochemical properties. In this work, calcium-binding agents, citric acid (CA) and sodium alginate (SA), were jointly introduced into α-tricalcium phosphate (α-TCP) cement to improve its physicochemical properties. Effects of CA and SA on the phase, morphology, deformation, handling and mechanical properties of the cement were further investigated. Co-existence of both agents significantly shortened the setting time whilst improved the anti-washout ability, injectability and mechanical strength of α-TCP cement in a CA-content-dependent manner. Rapid formation of SA-CA gel networks within the cement matrix enhanced the mobility of pastes with a strong cohesive action, which was beneficial for clinical injection. Herein, the conjunction of CA and SA was supposed to pave a way in developing injectable bone cement with good physicochemical properties for numerous clinical orthopedic applications.