PREVENTION OF COLLAGEN-INDUCED ARTHRITIS WITH AN ANTIBODY TO GP39, THE LIGAND FOR CD40
PREVENTION OF COLLAGEN-INDUCED ARTHRITIS WITH AN ANTIBODY TO GP39, THE LIGAND FOR CD40
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DOI：
10.1126/science.7689748
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发表时间：
1993-09-03
期刊：
影响因子：
56.9
通讯作者：
NOELLE, RJ
中科院分区：
文献类型：
--
作者：
DURIE, FH;FAVA, RA;NOELLE, RJ
CD 40抗原的配体是一种39千道尔顿的蛋白质gp 39，表达于活化的CD 4 + T细胞表面，是胸腺依赖性体液免疫所必需的。使用阻断其相互作用的抗体（抗gp 39）在体内研究了gp 39-CD 40相互作用在自身免疫性疾病中的作用。通过用II型胶原免疫小鼠诱导的关节炎被抗gp 39抑制。抗gp 39抗体阻断了关节炎症的发展、胶原蛋白的血清抗体滴度、炎性细胞向滑膜下组织的浸润以及软骨和骨的侵蚀。因此，干扰gp 39-CD 40相互作用可能在治疗自身免疫性疾病中具有治疗潜力。
The ligand for the CD40 antigen is a 39-kilodalton protein, gp39, expressed on the surface of activated CD4+ T cells and is essential for thymus-dependent humoral immunity. The role of gp39-CD40 interactions in autoimmune disease was investigated in vivo with the use of an antibody that blocks their interactions (anti-gp39). Arthritis induced in mice by immunization with type II collagen was inhibited by anti-gp39. Anti-gp39 blocked the development of joint inflammation, serum antibody titers to collagen, the infiltration of inflammatory cells into the subsynovial tissue, and the erosion of cartilage and bone. Thus, interference with gp39-CD40 interactions may have therapeutic potential in the treatment of autoimmune disease.