Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice
Koji glycosylceramide commonly contained in Japanese traditional fermented foods alters cholesterol metabolism in obese mice
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DOI：
10.1080/09168451.2018.1562877
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发表时间：
2019-08-03
影响因子：
1.6
通讯作者：
Kitagaki，Hiroshi
中科院分区：
文献类型：
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作者：
Hamajima，Hiroshi;Tanaka，Masaru;Kitagaki，Hiroshi
曲子是日本传统发酵食品的基地，是由非致病真菌米曲霉增殖而成的。我们发现，日本的发酵食品和饮料，如佐治酒、香曲酒、未过滤清酒和味增酒等，都含有丰富的糖神经酰胺。在这里，我们报告了给肥胖小鼠喂食高糖神经酰胺会改变胆固醇代谢。喂食高糖神经酰胺的肥胖小鼠的肝脏胆固醇显著降低。我们假设他们的肝脏胆固醇降低是因为它被转化为胆汁酸。与假设一致的是，喂食高糖神经酰胺的肥胖小鼠盲肠和粪便中的许多胆汁酸增加。饲喂高糖神经酰胺的小鼠肝脏中参与胆固醇代谢的细胞色素P7A1和ABCG8的表达显著增加。因此，认为高糖神经酰胺对肥胖小鼠的胆固醇代谢有影响。
Koji, which is manufactured by proliferating non-pathogenic fungusAspergillus oryzaeon steamed rice, is the base for Japanese traditional fermented foods. We have revealed thatkojiand related Japanese fermented foods and drinks such as amazake, shio-koji, unfiltered sake and miso contain abundant glycosylceramide. Here, we report that feeding ofkojiglycosylceramide to obese mice alters the cholesterol metabolism . Liver cholesterol was significantly decreased in obese mice fed withkojiglycosylceramide. We hypothesized that their liver cholesterol was decreased because it was converted to bile acids. Consistent with the hypothesis, many bile acids were increased in the cecum and feces of obese mice fed withkojiglycosylceramide. Expressions of CYP7A1 and ABCG8 involved in the metabolism of cholesterol were significantly increased in the liver of mice fed withkojiglycosylceramide. Therefore, it was considered thatkojiglycosylceramide affects the cholesterol metabolism in obese mice.