Sphingosine kinase and sphingosine-1-phosphate: regulators in autoimmune and inflammatory disease.
Sphingosine kinase and sphingosine-1-phosphate: regulators in autoimmune and inflammatory disease.
复制标题
DOI：
10.2217/ijr.13.40
复制
发表时间：
2013-08-01
期刊：
影响因子：
--
通讯作者：
Snider AJ
中科院分区：
文献类型：
--
作者：
Snider AJ
鞘脂及其代谢酶开始被认为是生物过程中的关键介质，特别是在炎症和自身免疫中。鞘氨醇激酶（SK）及其脂质产物鞘氨醇-1-磷酸（S1 P）在炎症信号传导过程以及疾病的发生和进展中起重要作用。SK可以被许多生长因子和细胞因子激活，包括TNF-α和IL-1β，导致S1 P的产生。S1 P对细胞内和细胞外靶点如S1 P受体发挥其生物学作用。除了在炎症信号传导途径中的作用，SK、S1 P和S1 P受体还涉及免疫细胞功能和运输，特别是在淋巴细胞中。本文就生物活性鞘脂S1 P、其生成酶SK及其细胞表面受体在系统性红斑狼疮、关节炎和炎症性肠病等炎症性和自身免疫性疾病中的作用作一综述。
Sphingolipids and their metabolizing enzymes are beginning to be recognized as critical mediators in biological processes, specifically in inflammation and autoimmunity. Sphingosine kinases (SKs) and their lipid product sphingosine-1-phosphate (S1P) play essential roles in inflammatory signaling processes, as well as disease development and progression. SKs can be activated by numerous growth factors and cytokines, including TNF-α and IL-1β, leading to the generation of S1P. S1P exerts its biological effects on intracellular and extracellular targets, such as S1P receptors. In addition to roles in inflammatory signaling pathways SKs, S1P and S1P receptors have been implicated in immune cell function and trafficking, specifically in lymphocytes. This review will discuss the contribution of the bioactive sphingolipid S1P, its generating enzyme SK, and its cell surface receptors in the inflammatory and autoimmune diseases systemic lupus erythematosus, arthritis and inflammatory bowel disease.