Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior
Fabrication of PLGA coated silica nanorattle for controlling the drug release behavior
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DOI：
10.1007/s11434-012-5246-4
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发表时间：
2012-07
影响因子：
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通讯作者：
Linlin Li;Yanqi Zhang;Nanjing Hao;Dong Chen;Fangqiong Tang
中科院分区：
文献类型：
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作者：
Linlin Li;Yanqi Zhang;Nanjing Hao;Dong Chen;Fangqiong Tang
具有中空和介孔结构的二氧化硅纳米柱是一种优良的药物载体。然而，如何控制药物从二氧化硅纳米阵列中的释放仍然是一个挑战。本研究设计了原位聚合法和水包油包水（W/O/W）复乳法两种方法，将纳米级的聚乳酸-羟基乙酸共聚物（PLGA）包覆在二氧化硅纳米柱表面，以控制药物的释放行为。将疏水性抗肿瘤药物多西他赛负载到PLGA涂覆的二氧化硅纳米阵列（PLGA@SN）中。评价了药物释放曲线、细胞摄取和对人肝癌HepG 2细胞的细胞毒性，以证明PLGA层在调节药物递送方面起着有效的作用。
Silica nanorattle with hollow and mesoporous structure has been proven to be an excellent drug carrier. However, how to control the drug release from silica nanorattle is still a challenge. In this study, we designed two methods,in-situpolymerization method and water in oil in water (W/O/W) double emulsion method, to coat a nanosized poly(lactic-co-glycolic acid) (PLGA) layer onto the surface of silica nanorattle for controlling the drug release behavior. Hydrophobic antitumor drug docetaxel was loaded into the PLGA coated silica nanorattle (PLGA@SN). The drug release profile, cellular uptake and cytotoxicity on human liver cancer HepG2 cells were evaluated to prove that the PLGA layer plays an effective role in tuning the drug delivery.