Nanotherapeutic systems for local treatment of brain tumors.
Nanotherapeutic systems for local treatment of brain tumors.
复制标题
DOI：
10.1002/wnan.1479
复制
发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Cui H
中科院分区：
文献类型：
--
作者：
Chakroun RW;Zhang P;Lin R;Schiapparelli P;Quinones-Hinojosa A;Cui H
恶性脑肿瘤，包括最常见的胶质母细胞瘤，是一种组织异质性和侵袭性的肿瘤，被认为是最具破坏性的肿瘤，发病率和死亡率都很高。尽管采取了手术、放射治疗、化疗和免疫治疗等多种治疗方法，但该病不可避免地会复发，而且是致命的。治疗方案的缺乏促使研究人员探索新的治疗策略和开发新的药物输送系统；然而，脑肿瘤独特的解剖、生理和病理特征极大地限制了传统化疗的有效性。在此背景下，我们综述了基于纳米颗粒的药物输送系统的最新进展，旨在解决将足够数量的治疗药物输送到脑肿瘤区域同时将潜在副作用降至最低的关键挑战。我们首先概述了目前临床上用于脑癌治疗的标准治疗方法，讨论了每种治疗方法的有效性和局限性。然后，我们对纳米治疗系统进行了深入的回顾，这些系统旨在绕过血脑屏障，克服多药耐药性，渗透到更大的肿瘤组织区域，和/或以受控的方式释放治疗剂。
Malignant brain tumor, including the most common type glioblastoma, are histologically heterogeneous and invasive tumors known as the most devastating neoplasms with high morbidity and mortality. Despite multimodal treatment including surgery, radiotherapy, chemotherapy, and immunotherapy, the disease inevitably recurs and is fatal. This lack of curative options has motivated researchers to explore new treatment strategies and to develop new drug delivery systems; however, the unique anatomical, physiological, and pathological features of brain tumors greatly limit the effectiveness of conventional chemotherapy. In this context, we review the recent progress in the development of nanoparticle-based drug delivery systems aiming to address the key challenges in transporting sufficient amount of therapeutic agents into the brain tumor areas while minimizing the potential side effects. We first provide an overview of the standard treatments currently used in the clinic for the management of brain cancers, discussing the effectiveness and limitations of each therapy. We then provide an in-depth review of nanotherapeutic systems that are intended to bypass the blood-brain barrier, overcome multidrug resistance, infiltrate larger tumorous tissue areas, and/or release therapeutic agents in a controlled manner.
登录
查看更多内容
影响因子：
11.2
作者：
Blank, C;Brown, I;Gajewski, TF
通讯作者：
Gajewski, TF
影响因子：
1.4
作者：
Adams, Hadie;Adams, Hieab H. H.;Quinones-Hinojosa, Alfredo
通讯作者：
Quinones-Hinojosa, Alfredo
DOI：
10.1007/s00259-008-0735-z
发表时间：
2008-10-01
影响因子：
9.1
作者：
Allard, E.;Hindre, F.;Benoit, J-P.
通讯作者：
Benoit, J-P.
影响因子：
13.5
作者：
Bodor, N;Buchwald, P
通讯作者：
Buchwald, P
影响因子：
14
作者：
Bhise, Nupura S.;Gray, Ryan S.;Sunshine, Joel C.;Htet, Soe;Ewald, Andrew J.;Green, Jordan J.
通讯作者：
Green, Jordan J.