Somato-motor inhibitory processing in humans: An event-related functional MRI study
Somato-motor inhibitory processing in humans: An event-related functional MRI study
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DOI：
10.1016/j.neuroimage.2007.10.041
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发表时间：
2008-02-15
期刊：
影响因子：
5.7
通讯作者：
Romani, Gian Luca
中科院分区：
文献类型：
--
作者：
Nakata, Hiroki;Sakamoto, Kiwako;Romani, Gian Luca
抑制不恰当的行为和想法是人类的一项基本能力，但负责抑制处理的区域一直存在争议。这是首次使用事件相关功能磁共振成像(FMRI)对躯体感觉GO/NOGO任务进行研究。15名被试执行了两种不同类型的GO/NOGO任务，即(1)运动和(2)计数，以与以往使用视觉GO/NOGO任务的研究进行比较，以确认抑制性加工是否依赖于感觉通道。GO和NOGO刺激的概率为偶数。我们的数据表明，反应抑制网络涉及背外侧(DLPFC)和腹外侧(VLPFC)前额叶皮质、前补充运动区(Pre-SMA)、前扣带回(ACC)、顶下小叶(IPL)、岛叶和颞顶交界区(TPJ)，这与以往使用视觉GO/NOGO任务获得的结果一致。这些活动在运动和Nogo伯爵审判中都存在。因此，我们的结果表明，抑制加工的网络不依赖于感觉方式，而是反映了共同的神经活动。此外，在运动和计数Nogo试验中，前额叶皮质、颞叶和ACC的激活强度也存在差异。因此，抑制处理将涉及两个神经网络，公共区域和非公共区域，取决于所需的反应模式。(C)2007 Elsevier Inc.保留所有权利。
Inhibiting inappropriate behavior and thoughts is an essential ability for humans, but the regions responsible for inhibitory processing are a matter of continuous debate. This is the first study of somatosensory go/nogo tasks using event-related functional magnetic resonance imaging (fMRI). Fifteen subjects preformed two different types of go/nogo task, i.e. (1) Movement and (2) Count, to compare with previous studies using visual go/nogo tasks, and confirm whether the inhibitory processing is dependent on sensory modalities. Go and nogo stimuli were presented with an even probability. Our data indicated that the response inhibition network involved the dorsolateral (DLPFC) and ventrolateral (VLPFC) prefrontal cortices, pre-supplementary motor area (pre-SMA), anterior cingulate cortex (ACC), inferior parietal lobule (IPL), insula, and temporoparietal junction (TPJ), which were consistent with previous results obtained using visual go/nogo tasks. These activities existed in both Movement and Count Nogo trials. Therefore, our results suggest that the network for inhibitory processing is not dependent on sensory modalities but reflects common neural activities. In addition, there were differences of activation intensity between Movement and Count Nogo trials in the prefrontal cortex, temporal lobe, and ACC. Thus, inhibitory processing would involve two neural networks, common and uncommon regions, depending on the required response mode. (c) 2007 Elsevier Inc. All rights reserved.