RENAL HEMODYNAMICS AND TUBULAR FUNCTION IN NORMAL HUMAN-PREGNANCY
RENAL HEMODYNAMICS AND TUBULAR FUNCTION IN NORMAL HUMAN-PREGNANCY
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DOI：
10.1038/ki.1980.124
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发表时间：
1980-01-01
影响因子：
19.6
通讯作者：
DUNLOP, W
中科院分区：
文献类型：
--
作者：
DAVISON, JM;DUNLOP, W
人类妊娠期肾功能的研究受到许多问题的困扰，切斯利对此进行了典型的清晰总结。即使使用最细致的方法，技术问题也会出现，结论往往必须从间接证据中得出。然而，已经积累了大量的文献(见参考文献)。研究肾功能必须克服的一个主要问题是不同受试者之间绝对值的巨大差异。在非妊娠状态下，这在一定程度上可以通过将数据修正到1.73平方米的标准体表面积(因此，隐含着标准的肾脏大小)来解决[3]。然而，在怀孕期间，表面积诺模图不再适用[4]，因此，研究肾脏变化的唯一现实方法是将每个受试者作为自己的对照，即在怀孕和非怀孕状态下对同一受试者进行系列研究。这种繁重的工作只是偶尔进行，但如果忽视这一原则，可能会完全错过功能的重大变化，并可能得出错误的结论。本文试图描述人类怀孕期间发生的肾血流动力学和肾小管功能的某些方面的变化，特别是尿酸和葡萄糖的处理。
The study of renal function in human pregnancy is beset by many problems, summarized with exemplary clarity by Chesley [1]. Technical problems occur even with the most meticulous methodology, and conclusions must often be drawn from indirect evidence. Nevertheless, there has accumulated an extensive literature (see Ref. 2), from which general trends may be discerned.A major problem that must be overcome in studying renal function is the wide variation in absolute values between individual subjects. In the nonpregnant state, this may be resolved to some extent by correcting data to a standard body surface area of 1.73 m2(and thus, by implication, to a standard kidney size) [3]. In pregnancy, however, the surface area nomogram is no longer applicable [4], The only realistic way to investigate renal changes, therefore, is to use each subject as her own control, that is, to perform serial studies on the same subject during pregnancy and in the nonpregnant state. Such demanding work has only occasionally been performed, but if the principle is neglected, significant changes in function may be missed altogether and erroneous conclusions may be drawn.This paper attempts to describe the changes that occur during human pregnancy in renal hemodynamics and in certain aspects of tubular function, particularly the handling of uric acid and glucose.