GIANT MITOCHONDRIA IN THE MYOCARDIUM OF AGING AND ENDURANCE-TRAINED MICE
GIANT MITOCHONDRIA IN THE MYOCARDIUM OF AGING AND ENDURANCE-TRAINED MICE
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DOI：
10.1159/000212851
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发表时间：
1987-01-01
期刊：
影响因子：
3.5
通讯作者：
REZNICK, AZ
中科院分区：
文献类型：
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作者：
COLEMAN, R;SILBERMANN, M;REZNICK, AZ
在超微结构研究的过程中，对实验性雌性C57 BL/6 J小鼠，年龄在6和27个月之间，左心室心肌的顶点区域，并已受到长期的每日强制耐力跑时间表，我们遇到了一些不寻常的巨型线粒体的情况。这些线粒体表现出退行性变化，包括嵴的破坏、解体和丢失以及电子透明基质的形成。在许多情况下，这些巨大的线粒体显示出密集的内含物与基质。巨大的线粒体似乎是由于相邻的肥大线粒体之间的融合，随后发生一系列进行性退行性变化而形成的。这些巨大的线粒体最常见于遵循耐力训练计划10或15个月的小鼠的心肌中，而在年龄匹配的非跑步对照小鼠中没有遇到。
During the course of an ultrastructural study on the apex region of the left ventricular myocardium of experimental female C57BL/6J mice, aged between 6 and 27 months, and that had been subjected to long-term daily enforced endurance running schedules, we encountered some instances of unusual giant mitochondria. These mitochondria showed degenerative changes including the disruption, disorganization and loss of cristae and the development of a very electron-lucent matrix. In many instances, these giant mitrochondria showed dense inclusions with the matrix. The giant mitochondria appear to have developed as a result of fusion between adjacent hypertrophic mitochondria followed by a sequence of progressive degenerative changes. These giant mitochrondria were most common in the myocardium of mice that had followed endurance training schedules for 10 or 15 months and were not encountered in age-matched nonrunning control mice.