Copper-catalyzed enantioselective Mukaiyama aldol reaction of silyl enol ethers with isatins
Copper-catalyzed enantioselective Mukaiyama aldol reaction of silyl enol ethers with isatins
复制标题
铜催化硅烯醇醚与靛红的对映选择性Mukaiyama羟醛反应
DOI：
10.1039/c9cc02159k
复制
发表时间：
2019-06-04
影响因子：
4.9
通讯作者：
Wang, Zhiyong
中科院分区：
文献类型：
--
作者：
Li, Jindong;Li, Yanan;Wang, Zhiyong
研究了硅烯醇醚与isatins的高对映选择性Mukaiyama醛醇反应。该方法可获得一系列手性3-取代- 3-羟基-2-氧吲哚，收率高达95%，对映选择性高达99%。特别是，水对于提高非对映选择性是必不可少的。
A highly enantioselective Mukaiyama aldol reaction of silyl enol ethers with isatins was developed. A series of chiral 3-substituted 3-hydroxy-2-oxindoles could be obtained exclusively with high yields (up to 95%) and excellent enantioselectivities (up to 99%). In particular, water was essential to improve the diastereoselectivity.