Polydopamine-Based "Four-in-One" Versatile Nanoplatforms for Targeted Dual Chemo and Photothermal Synergistic Cancer Therapy
Polydopamine-Based "Four-in-One" Versatile Nanoplatforms for Targeted Dual Chemo and Photothermal Synergistic Cancer Therapy
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基于聚多巴胺的“四合一”多功能纳米平台，用于靶向双化疗和光热协同癌症治疗
DOI：
10.3390/pharmaceutics11100507
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发表时间：
2019-10-01
期刊：
影响因子：
5.4
通讯作者：
Deng, Wenbin
中科院分区：
文献类型：
--
作者：
Liu, Gan;Gao, Nansha;Deng, Wenbin
目前迫切需要开发一种能与多种治疗药物或方法相结合并提高癌症治疗效果的多功能纳米级药物递送系统。为了满足这一需求，聚多巴胺（PDA）修饰的聚合物纳米平台被构建用于双重装载化疗药物。将疏水性抗癌药物多西他赛（DTX）负载到由星形共聚物CA-PLGA制成的聚合物纳米粒（NPs）中。然后用PDA包被载药纳米粒，然后与聚乙二醇（PEG）修饰的靶向配体适配体AS 1411（Apt）偶联并吸附亲水性抗癌药物阿霉素（DOX）。这种“四合一”纳米平台，称为DTX/NPs@PDA/DOX-PEG-Apt，表现出高的近红外光热转换效率，并表现出pH和热响应性药物释放行为。此外，它能够特异性靶向MCF-7人乳腺癌细胞，并提供协同的化学-光热治疗，以进一步提高体外和体内的抗癌效果，为癌症治疗提供了一种新的有前途的策略。
The development of versatile nanoscale drug delivery systems that integrate with multiple therapeutic agents or methods and improve the efficacy of cancer therapy is urgently required. To satisfy this demand, polydopamine (PDA)-modified polymeric nanoplatforms were constructed for the dual loading of chemotherapeutic drugs. The hydrophobic anticancer drug docetaxel (DTX) was loaded into the polymeric nanoparticles (NPs) which were fabricated from the star-shaped copolymer CA-PLGA. Then DTX-loaded NPs were coated with PDA, followed by conjugation of polyelethyl glycol (PEG)-modified targeting ligand aptamer AS1411(Apt) and adsorption of the hydrophilic anticancer drug doxorubicin (DOX). This "four-in-one" nanoplatform, referred to as DTX/NPs@PDA/DOX-PEG-Apt, demonstrated high near-infrared photothermal conversion efficiency and exhibited pH and thermo-responsive drug release behavior. Furthermore, it was able to specifically target MCF-7 human breast carcinoma cells and provide synergistic chemo-photothermal therapy to further improve the anticancer effect both in vitro and in vivo, providing a novel promising strategy for cancer therapy.