Dose reconstruction for individuals exposed to ionizing radiation using chromosome painting.
Dose reconstruction for individuals exposed to ionizing radiation using chromosome painting.
复制标题
使用染色体涂色对暴露于电离辐射的个体进行剂量重建。
作者：
J. Lucas
To be most useful, a biomarker for dose reconstruction should employ an end point that is highly quantitative, stable with time and easily measured. Reciprocal translocations have been shown to be a promising biomarker that is linked to both prior exposure and risk, and they can be measured easily and quantitatively using fluorescence in situ hybridization. In contrast to other biomarkers that are available, the frequency of reciprocal translocations in individuals exposed to whole-body radiation is stable with time after exposure, has rather small interindividual variability and can be measured accurately at low levels of exposure. Results from recent studies demonstrate that measurements of reciprocal translocation frequencies, facilitated by chromosome painting, can be used to reconstruct radiation dose for individuals exposed in the distant past.
