Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability
Microfluidic fabrication of monodisperse biocompatible and biodegradable polymersomes with controlled permeability
复制标题
DOI：
10.1021/ja802157y
复制
发表时间：
2008-07-23
影响因子：
15
通讯作者：
Weitz, David A.
中科院分区：
文献类型：
--
作者：
Shum, Ho Cheung;Kim, Jin-Woong;Weitz, David A.
我们描述了一种利用生物相容性和可生物降解的二嵌段共聚物制造单分散聚合物囊泡的通用技术，以有效封装活性物质。我们使用双乳液作为模板将两亲性二嵌段共聚物组装成囊泡结构。这些聚合物囊泡可用于封装小的亲水性溶质。当渗透压休克触发时，聚合物囊泡破裂并释放溶质，提供了简单而有效的释放机制。该技术还可以应用于具有不同亲水性与疏水性嵌段比率的二嵌段共聚物，或二嵌段共聚物和疏水性均聚物的混合物。用不同嵌段比的共聚物制造聚合物囊泡以及将不同的均聚物掺入聚合物囊泡中的能力将允许针对特定技术应用调整聚合物囊泡的性质。
We describe a versatile technique for fabricating monodisperse polymersomes with biocompatible and biodegradable diblock copolymers for efficient encapsulation of actives. We use double emulsion as a template for the assembly of amphiphilic diblock copolymers into vesicle structures. These polymersomes can be used to encapsulate small hydrophilic solutes. When triggered by an osmotic shock, the polymersomes break and release the solutes, providing a simple and effective release mechanism. The technique can also be applied to diblock copolymers with different hydrophilic-to-hydrophobic block ratios, or mixtures of diblock copolymers and hydrophobic homopolymers. The ability to make polymer vesicles with copolymers of different block ratios and to incorporate different homopolymers into the polymersomes will allow the tuning of polymersome properties for specific technological applications.