Parkinson's disease
Parkinson's disease
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DOI：
10.1212/wnl.35.8.1215
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发表时间：
1985-08
期刊：
影响因子：
9.9
通讯作者：
G. Uhl;J. Hedreen;D. Price
中科院分区：
文献类型：
--
作者：
G. Uhl;J. Hedreen;D. Price
多巴胺能黑质纹状体系统的色素神经元数量减少是帕金森病（PD）患者大脑中最显著的病理学，但很明显，蓝斑、迷走神经核和Meynert基底核中的神经元也受到这种疾病的影响。由于神经化学证据表明，起源于腹侧被盖区（VTA）的中脑边缘多巴胺能系统也可能参与，本研究的目的是评估中脑边缘多巴胺系统在PD的着色神经元计数VTA对侧的治疗性病变放置在基底神经节或丘脑。在PD中，VTA神经元被耗尽至对照值的36%至55%。此外，VTA显示过多的游离色素，这是色素神经元死亡的标志。这些变化可能是重要的运动障碍或精神状态发生在PD。
Decreased numbers of pigmented neurons of the dopaminer-gic nigrostriatal system are the most striking pathology in the brains of individuals with Parkinson's disease (PD), but it is clear that neurons in the locus ceruleus, vagal nuclei, and nucleus basalis of Meynert are also affected in this disease. Because neurochemical evidence suggested that the mesolimbic dopaminergic system originating in the ventral tegmental area (VTA) may also be involved, the present study was designed to evaluate the mesolimbic dopamine system in PD by counting pigmented neurons in the VTA contralateral to therapeutic lesions placed in the basal ganglia or thalamus. In PD, VTA neurons were depleted to 36 to 55% of control values. Moreover, the VTA showed excessive free pigment, a marker for death of pigmented neurons. These changes may be important in disorders of movement or mentation occurring in PD.