Complete resection after imatinib treatment of a gastrointestinal stromal tumor of the ileum with peritoneal metastases: Report of a case
Complete resection after imatinib treatment of a gastrointestinal stromal tumor of the ileum with peritoneal metastases: Report of a case
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DOI：
10.1007/s00595-008-4037-7
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发表时间：
2010-03-01
期刊：
影响因子：
2.5
通讯作者：
Muto, Tetsuichiro
中科院分区：
文献类型：
--
作者：
Akiyoshi, Takashi;Oya, Masatoshi;Muto, Tetsuichiro
一位70岁女性盆腔肿瘤患者在另一家医院接受腹腔镜探查，发现许多腹膜结节。腹膜结节活检标本的免疫组织化学染色呈KIT阳性。因此，诊断为胃肠道间质瘤（GIST），并开始伊马替尼治疗。经过16个月的治疗后，肿瘤大小从51 x 55 mm降至22 x 17 mm，并进行了手术。剖腹手术显示腹膜病变完全消退。原发性肿瘤起源于小肠，并松散地粘附在直肠上。我们做了部分小肠切除术。术后1个月重新开始伊马替尼治疗，随访12个月后患者情况良好。我们报告这种情况下，表明有治愈性挽救手术的可能性，长期伊马替尼治疗后，一些患者腹膜转移的胃肠道间质瘤。
A 70-year-old woman with a pelvic tumor had undergone exploratory laparoscopy at another institution, which revealed many peritoneal nodules. Immunohistochemical staining of a biopsy specimen of the peritoneal nodules was positive for KIT. Thus, a gastrointestinal stromal tumor (GIST) was diagnosed and imatinib treatment was begun. After 16 months of this treatment, the tumor size had decreased from 51 x 55 mm to 22 x 17 mm, and surgery was performed. Laparotomy revealed complete regression of the peritoneal lesions. The primary tumor was seen to arise from the small intestine and to loosely adhere to the rectum. We performed partial resection of the small intestine. Imatinib therapy was restarted 1 month postoperatively, and the patient is doing well after 12 months of follow-up. We report this case to show that there is the possibility of curative salvage surgery after long-term imatinib treatment in some patients with peritoneal metastases of a GIST.