Covalent Tethers for Precise Amino Alcohol Syntheses: Ring Opening of Epoxides by Pendant Sulfamates and Sulfamides.
Covalent Tethers for Precise Amino Alcohol Syntheses: Ring Opening of Epoxides by Pendant Sulfamates and Sulfamides.
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用于精确氨基醇合成的共价键：通过悬垂的氨基磺酸盐和磺酰胺使环氧化物开环。
DOI：
10.1021/acs.orglett.3c00053
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发表时间：
2023
期刊：
影响因子：
5.2
通讯作者：
Sathyamoorthi,Shyam
中科院分区：
文献类型：
--
作者：
Nagamalla,Someshwar;Mague,JoelT;Sathyamoorthi,Shyam
我们描述了发展的第一环开放的环氧化物使用悬垂氨基磺酸酯和磺酰胺。这些反应是由碱促进，并在温和的条件下进行，得到氧噻嗪烷和环磺酰胺具有良好的非对映选择性和区域控制。反应规模很好，产物作为开环反应的催化剂。
We describe the development of the first ring opening of epoxides using pendant sulfamates and sulfamides. These reactions are promoted by a base and proceed under mild conditions to afford oxathiazinanes and cyclic sulfamides with excellent diastereoselectivity and regiocontrol. The reactions scale well, and the products serve as synthons for ring-opening reactions.