Cytogenetics of melanoma and nonmelanoma skin cancer
Cytogenetics of melanoma and nonmelanoma skin cancer
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DOI：
10.1007/978-0-387-77574-6_18
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发表时间：
2008-01-01
期刊：
影响因子：
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通讯作者：
Griffiths, Lyn R.
中科院分区：
文献类型：
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作者：
Carless, Melanie A.;Griffiths, Lyn R.
黑色素瘤和非黑色素瘤皮肤癌的细胞遗传学分析揭示了复发性畸变，其频率反映了恶性潜能。高度异常核型见于黑色素瘤、鳞状细胞癌、日光性角化病和默克尔细胞癌，而稳定核型见于基底细胞癌、角化棘皮瘤、Bowen病、隆突性皮肤纤维肉瘤和皮肤淋巴瘤。一些畸变在许多皮肤癌类型中是常见的，包括染色体1、-3p、+3q、部分或全部6三体、7三体、+8q、-9p、+9q、染色体10、-17p、+17q的部分或全部丢失以及染色体20的部分或全部获得的重排和数值异常。细胞遗传学分析与其他分子遗传学技术相结合，不仅能够识别异常染色体区域，而且能够识别导致恶性表型的基因。本文综述了与各种黑色素瘤和非黑色素瘤皮肤癌相关的细胞遗传学畸变。
Cytogenetic analysis of melanoma and nonmelanoma skin cancers has revealed recurrent aberrations, the frequency of which is reflective of malignant potential. Highly aberrant karyotypes are seen in melanoma, squamous cell carcinoma, solar keratosis and Merkel cell carcinoma with more stable karyotypes seen in basal cell carcinoma, keratoacanthoma, Bowen's disease, dermatofibrosarcoma protuberans and cutaneous lymphomas. Some aberrations were common amongst a number of skin cancer types including rearrangements and numerical abnormalities of chromosome 1, -3p, +3q, partial or entire trisomy 6, trisomy 7, +8q, -9p, +9q, partial or entire loss of chromosome 10, -17p, +17q and partial or entire gain of chromosome 20. Combination of cytogcnetic analysis with other molecular genetic techniques has enabled the identification of not only aberrant chromosomal regions, but also the genes that contribute to a malignant phenotype. This review provides a comprehensive summary of the pertinent cytogenetic aberrations associated with a variety of melanoma and nonmelanoma skin cancers.