Reductive Couplings of 2-Halopyridines without External Ligand: Phosphine-Free Nickel-Catalyzed Synthesis of Symmetrical and Unsymmetrical 2,2′-Bipyridines
Reductive Couplings of 2-Halopyridines without External Ligand: Phosphine-Free Nickel-Catalyzed Synthesis of Symmetrical and Unsymmetrical 2,2′-Bipyridines
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无需外部配体的 2-卤代吡啶的还原偶联：无膦镍催化合成对称和不对称 2,2'-联吡啶
DOI：
10.1021/jo402084m
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发表时间：
2014-01-17
影响因子：
3.6
通讯作者：
Duan, Xin-Fang
中科院分区：
文献类型：
--
作者：
Liao, Lian-Yan;Kong, Xing-Rui;Duan, Xin-Fang
通过镍催化2-卤吡啶的还原偶联，提出了一种意想不到的简便合成对称和不对称2,2'-联吡啶的方法。在不使用外部配体的情况下，用5 mol %的NiCl2中心点6H(2)O有效催化了偶联反应。合成了包括绿霉素F在内的多种2,2′-联吡啶类化合物。
An unexpectedly facile synthetic approach for symmetrical and unsymmetrical 2,2'-bipyridines through the Ni-catalyzed reductive couplings of 2-halopyridines was developed. The couplings were efficiently catalyzed by 5 mol % of NiCl2 center dot 6H(2)O without the use of external ligands. A variety of 2,2'-bipyridines including caerulomycin F have been efficiently synthesized.