Validity of PROMIS physical function measured in diverse clinical samples
Validity of PROMIS physical function measured in diverse clinical samples
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DOI：
10.1016/j.jclinepi.2015.08.039
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发表时间：
2016-05-01
影响因子：
7.2
通讯作者：
Cella, David
中科院分区：
文献类型：
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作者：
Schalet, Benjamin D.;Hays, Ron D.;Cella, David
目的：使用6种慢性健康状况中收集的纵向数据评估患者报告结果测量信息系统（PROMIS）身体功能测量的有效性。研究设计和设置：患有类风湿性关节炎（RA）、重度抑郁症（MDD）、背痛、慢性阻塞性肺病（COPD）、慢性心力衰竭（CHF）的个体，和癌症患者在基线和临床相关随访期结束时完成PROMIS身体功能计算机化自适应测试或固定长度的简短表格。还进行了锚项目，以评估身体功能和一般健康状况的变化。线性混合效应模型和标准化的反应手段估计在基线和follow-up.Results：共1,415人参加（COPD n = 121; CHF n = 57;背痛n = 218; MDD n = 196; RA n = 521;癌症n = 302）。治疗CHF和背痛患者的PROMIS身体功能评分显著改善，但MDD或COPD患者的PROMIS身体功能评分无改善。大多数的病人子样本，报告改善或恶化的锚显示相应的积极或消极的变化PROMIS物理Function.Conclusion：这项研究提供的证据表明，PROMIS物理功能措施是敏感的干预研究中的物理功能的变化，预计将改变，并能够区分不同的临床样本。结果告知有意义的变化的估计，使比较有效性研究。(C)2016 Elsevier Inc. All rights reserved.
Objectives: To evaluate the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function measures using longitudinal data collected in six chronic health conditions.Study Design and Setting: Individuals with rheumatoid arthritis (RA), major depressive disorder (MDD), back pain, chronic obstructive pulmonary disease (COPD), chronic heart failure (CHF), and cancer completed the PROMIS Physical Function computerized adaptive test or fixed-length short form at baseline and at the end of clinically relevant follow-up intervals. Anchor items were also administered to assess change in physical function and general health. Linear mixed-effects models and standardized response means were estimated at baseline and follow-up.Results: A total of 1,415 individuals participated (COPD n = 121; CHF n = 57; back pain n = 218; MDD n = 196; RA n = 521; cancer n = 302). The PROMIS Physical Function scores improved significantly for treatment of CHF and back pain patients but not for patients with MDD or COPD. Most of the patient subsamples that reported improvement or worsening on the anchors showed a corresponding positive or negative change in PROMIS Physical Function.Conclusion: This study provides evidence that the PROMIS Physical Function measures are sensitive to change in intervention studies where physical function is expected to change and able to distinguish among different clinical samples. The results inform the estimation of meaningful change, enabling comparative effectiveness research. (C) 2016 Elsevier Inc. All rights reserved.