Evolution of subspecies of Francisella tularensis
Evolution of subspecies of Francisella tularensis
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DOI：
10.1128/jb.187.11.3903-3908.2005
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发表时间：
2005-06-01
影响因子：
3.2
通讯作者：
Johansson, A
中科院分区：
文献类型：
--
作者：
Svensson, K;Larsson, P;Johansson, A
单向基因组缺失事件和单核苷酸变异分析表明，土拉弗朗西斯菌的四个亚种是通过垂直下降进化而来的。分析表明，在进化过程中，高毒力的土拉菌亚种。土拉菌（A型）出现在毒性较弱的土拉菌亚种之前。全北极（B型）。与毒力强的祖菌相比，土拉菌减毒株表现出特异性的单向基因丢失。
Analysis of unidirectional genomic deletion events and single nucleotide variations suggested that the four subspecies of Francisella tularensis have evolved by vertical descent. The analysis indicated an evolutionary scenario where the highly virulent F. tularensis subsp. tularensis (type A) appeared before the less virulent F. tularensis subsp. holarctica (type B). Compared to their virulent progenitors, attenuated strains of F. tularensis exhibited specific unidirectional gene losses.