Lessons from old and new kinases.
Lessons from old and new kinases.
复制标题
新旧激酶的经验教训。
DOI：
10.1161/01.res.0000117526.17737.40
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发表时间：
2004
影响因子：
20.1
通讯作者：
VanEyk,JE
中科院分区：
文献类型：
--
作者：
VanEyk,JE
Elucidating the central role of protein phosphorylation in the regulation of muscle contraction on both beatto-beat and long-term bases began with a series of classical studies starting in the mid-1970s. 1, 2 Despite years of extensive studies, two articles in this issue of Circulation Research3, 4 demonstrate that there is still a great deal to be learned about the complexity of the myocyte and its regulation by kinases.Protein kinase A (PKA) has been studied using purified proteins, isolated subproteomes, isolated myocytes, intact heart preparations, and in vivo animal studies, and yet we still do not have the whole picture. The work presented by Chu et al3 provides a tantalizing glimpse into widespread protein changes occurring in isolated myocytes with isoproterenol treatment. Although phosphorylation of the regulatory proteins phospholamban and cardiac troponin I (cTnI) under ß-adrenergic stimulation has been well-characterized, it is
