Case-control study of 24 hour ambulatory blood pressure in patients with obstructive sleep apnoea and normal matched control subjects

Case-control study of 24 hour ambulatory blood pressure in patients with obstructive sleep apnoea and normal matched control subjects
复制标题

DOI：
10.1136/thorax.55.9.736
复制
发表时间：
2000-09-01
期刊：
THORAX
影响因子：
10
通讯作者：
Stradling, JR
Stradling, JR
中科院分区：
医学1区
文献类型：
--
作者：
Davies, CWH;Crosby, JH;Stradling, JR

文献摘要

被引文献

相似文献

背景：阻塞性睡眠呼吸暂停（OSA）与高血压之间的关系存在相当大的争议。目前尚不清楚OSA是否是一个独立的血管危险因素，因为试图评估其相关性的研究由于上半身肥胖、酒精和吸烟等混杂变量而产生了相互矛盾的结果。在OSA患者和匹配的对照组中进行了24小时动态血压的病例对照研究，以评估OSA是否是每日高血压的独立相关因素。方法：45例中重度OSA伴白天嗜睡的患者与45例无OSA的对照组进行睡眠研究。匹配的变量包括年龄、身体质量指数（BMI）、饮酒、吸烟、高血压治疗和缺血性心脏病。上半身肥胖通过腰臀比和腰高比进行比较；对所有受试者进行24小时动态血压记录（治疗前）。结果：OSA患者白天平均（SD）舒张压（mm Hg）均显著升高(87.4 (10.2)vs 82.8 (9.1))；p=0.03，平均差异4.6 （95% CI 0.7 ~ 8.6）和夜间时间（78.6（9.3）对71.4 (8.0)）；p
Background-There is considerable debate regarding the relationship between obstructive sleep apnoea (OSA) and hypertension. It is unclear whether OSA is an independent vascular risk factor as studies attempting to assess this association have produced conflicting results because of confounding variables such as upper body obesity, alcohol, and smoking. A case-control study of 24 hour ambulatory blood pressure was undertaken in patients with OSA and matched controls to assess whether OSA is an independent correlate of diurnal hypertension.Methods-Forty five patients with moderate to severe OSA and excessive daytime sleepiness were matched with 45 controls without OSA in a sleep study. Matched variables included age, body mass index (BMI), alcohol, cigarette usage, treated hypertension, and ischaemic heart disease. Upper body obesity was compared by waist:hip and waist:height ratios; 24 hour ambulatory blood pressure recordings were performed (before treatment for OSA) in all subjects.Results-Patients with OSA had significantly increased mean (SD) diastolic blood pressure (mm Hg) during both daytime (87.4 (10.2) versus 82.8 (9.1); p=0.03, mean difference 4.6 (95% CI 0.7 to 8.6) and night time (78.6 (9.3) versus 71.4 (8.0); p