Neural Specificity of Acupuncture Stimulation at Pericardium 6: Evidence From an FMRI Study
Neural Specificity of Acupuncture Stimulation at Pericardium 6: Evidence From an FMRI Study
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针刺刺激心包的神经特异性 6：来自 FMRI 研究的证据
DOI：
10.1002/jmri.22006
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发表时间：
2010-01-01
影响因子：
4.4
通讯作者：
Tian, Jie
中科院分区：
文献类型：
--
作者：
Bai, Lijun;Yan, Hao;Tian, Jie
目的：为探讨心包PC6的神经特异性，以同一经络穴位PC 7和治疗无关穴位GB 37作为单独对照，材料与方法：对36名健康受试者进行全脑功能磁共振成像（MRI），分别针刺三个穴位：研究穴位（PC6）。对照组（PC 7、GB 37）。采用一种新的非重复事件相关（NRER）设计范式，分别检测与针刺不同阶段（针刺手法和针刺后休息期）相关的神经活动。心理物理反应（德气的感觉）也assessed.Results：神经iniaging研究的PC6提出了广泛的信号衰减在小脑和皮质下区，而针刺在GB 37引起广泛的信号增强。此外，针刺PC6，与刺激PC 7和GB 37相比。选择性地诱发下丘脑的神经反应。结论：本研究为针刺PC6后小脑-下丘脑和小脑下丘脑参与前庭功能的自主调节提供了初步证据。在这些区域中的主要时间延长的失活也可能有助于PC6在止吐治疗中产生镇静或镇静作用的临床功效。
Purpose: To investigate the neural specificity of pericardium PC6, with the same meridian acupoint PC7 and a treatment-irrelevant acupoint GB37 as separate controls.Materials and Methods: Functional magnetic resonance imaging (MRI) of the whole brain was performed in 36 healthy subjects receiving acupuncture at three acupoints, respectively: the study acupoint (PC6). and control acupoints (PC7 and GB37). A novel nonrepeated event-related (NRER) design paradigm was applied to separately detect neural activities related to different stages of acupuncture (needling manipulation and post-acupuncture rest epoch). Psychophysical responses (Deqi sensations) were also assessed.Results: Neuroiniaging studies of PC6 presented extensive signal attenuations in the cerebrocerebellar and subcortical areas, whereas acupuncture at GB37 induced widespread signal potentiations. In addition, acupuncture at PC6, in comparison with stimulations at PC7 and GB37. selectively evoked neural responses of the insula, hypothalamus. and flocculonodular lobe of cerebellum (nodulus and uvula).Conclusion: These findings may provide preliminary evidence for specific involvements of the cerebellar-hypothalamus and insula following acupuncture at PC6, which underlies the autonomic regulation of vestibular functions. The predominantly time-prolonged deactivations in these areas may also serve the clinical efficacy of PC6 in producing a sedative or tranquilizing effect in antiemetic treatment.