Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain
Denervation of dopaminergic neurons with 6-hydroxydopamine increases nerve growth factor content in rat brain
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DOI：
10.1016/0304-3940(92)90738-s
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发表时间：
1992-09
影响因子：
2.5
通讯作者：
A. Nitta;Y. Furukawa;K. Hayashi;M. Hiramatsu;T. Kameyama;T. Hasegawa;T. Nabeshima
中科院分区：
文献类型：
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作者：
A. Nitta;Y. Furukawa;K. Hayashi;M. Hiramatsu;T. Kameyama;T. Hasegawa;T. Nabeshima
通过黑质内注射6-羟基多巴胺（6-OHDA）使多巴胺能神经元去神经化，增加了皮质和海马中神经生长因子（NGF）的含量，这两者都由胆碱能神经元支配。在病变后0.5-28天的观察期内持续增加。神经生长因子含量变化的时间过程与胆碱能神经元失神经支配的时间过程有很大不同。在观察期内，6-OHDA注射引起的纹状体多巴胺含量降低未恢复。这些结果表明，多巴胺能神经元损伤可能会影响NGF的合成。
Denervation of dopaminergic neurons by intra nigral injection of 6-hydroxydopamine (6-OHDA) increased nerve growth factor (NGF) content in the cortex and hippocampus, both of which are innervated by cholinergic neurons. The increase continued during an observation period of 0.5–28 days after the lesion. The time course of changes in NGF content was quite different from that of cholinergic neuron denervation. The decreased dopamine content produced in the striatum by 6-OHDA injection was not recovered during the observation period. These results suggest that dopaminergic neuron damage may affect NGF synthesis.