A Histopathologic Comparison of Eustachian Tube Anatomy in Pediatric and Adult Temporal Bones.
A Histopathologic Comparison of Eustachian Tube Anatomy in Pediatric and Adult Temporal Bones.
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儿童和成人颞骨咽鼓管解剖结构的组织病理学比较。
DOI：
10.1097/mao.0000000000002112
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Miller,MiaE
中科院分区：
文献类型：
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作者：
Noonan,KathrynY;Linthicum,FredH;Lopez,IvanA;Ishiyama,Akira;Miller,MiaE
背景：用ET扩张治疗ET功能障碍是FDA批准用于成人的。一些研究描述了成人CC和ET之间的密切关系，但ET的解剖结构在儿童中尚未得到很好的定义。本研究旨在探讨这些关系在pediatric population.Methods：组织切片从23个儿童患者的年龄0至18岁的颞骨进行了审查，由两个独立的观察员。测量CC与软骨咽鼓管（CET）、骨软骨交界处（BCJ）和骨性咽鼓管（BET）的距离。15个成人颞骨被用作对照组。结果：到CC的距离在BET是最远的，实际上是更高的儿童人群相比，成人（0.5毫米和0.2毫米，分别为p= 0.06）。儿童组的CC-CET距离较小（2.3 mm vs 3.3 mm，p< 0.01）。骨-软骨交界处通常是扩张过程中最受关注的区域。儿童组和成人组的CC-BET距离无显著差异（1.9 vs 2.3 mm，p= 0.20）。结论：由于解剖结构较小，儿童人群的CET-CC较小。然而，ET的可变倾斜导致CC-BCJ距离与成年人群相似。尽管影像学检查是必要的。
Background:ET dysfunction treated with ET dilation is FDA approved for adults. Several studies describe the close relationship between the CC and the ET in adults, but the anatomy of the ET has not been well defined in children. This study seeks to investigate these relationships in the pediatric population.Methods:Histologic sections from 23 temporal bones of pediatric patients ages 0 to 18 were reviewed by two independent observers. The distance between the CC and the cartilaginous Eustachian tube (CET), bony-cartilaginous junction (BCJ), and bony Eustachian tube (BET) were measured. Fifteen adult temporal bones were used as a control group.Results:The distance to the CC was narrowest at the BET, and was actually higher in the pediatric population when compared to adults (0.5 mm and 0.2 mm, respectively, p= 0.06). The CC-CET distance was smaller in the pediatric group (2.3 mm vs 3.3 mm, p< 0.01). The bony-cartilaginous junction is often the region of most concern during dilation. There was no significant difference between the CC-BET distance in pediatric and adult groups (1.9 vs 2.3 mm, p= 0.20).Conclusions:CET-CC is smaller in the pediatric population, as expected due to smaller anatomic structures. However, the variable incline of the ET results in a CC-BCJ distance that is similar to the adult population. Although imaging studies are necessary.