Comparison of Three Fractionation Schedules in Radiotherapy for Early Glottic Squamous Cell Carcinoma
Comparison of Three Fractionation Schedules in Radiotherapy for Early Glottic Squamous Cell Carcinoma
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DOI：
10.21873/invivo.12101
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发表时间：
2020-09-01
期刊：
影响因子：
2.3
通讯作者：
Yamada, Kei
中科院分区：
文献类型：
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作者：
Suzuki, Gen;Yamazaki, Hideya;Yamada, Kei
背景/目的：放射治疗被广泛接受为早期声门型鳞状细胞癌（EGSCC）的治疗选择，虽然它在剂量，剂量每部分，和治疗技术方面有很大的差异。本研究的目的是评估在标准临床实践中EGSCC加速分割策略（AFS）的使用。患者和方法：回顾性确定了2008年至2019年期间接受EGSCC确定性放疗的患者，并接受了常规分割、低分割或超分割。结果如下：分析了106例患者，分别有19例、71例和16例患者接受了常规分割、低分割和超分割。中位随访时间为56个月。5年局部控制率和总生存率分别为79%和83%; 78%和79%; 87%和77%，并且在分割方案之间没有观察到显著差异。结论：我们的研究结果证实了AFS在标准临床实践中的实用性，并支持其用于EGSCC患者。
Background/Aim: Radiotherapy is widely accepted as the treatment of choice for early glottic squamous cell carcinoma (EGSCC), although it varies greatly with respect to dose, dose per fraction, and treatment techniques. The study aim was to evaluate the use of accelerated fractionation strategy (AFS) for EGSCC in standard clinical practice. Patients and Methods: Patients treated with definitive radiotherapy for EGSCC between 2008 and 2019 were retrospectively identified and received either conventional fractionation, hypofractionation, or hyperfractionation. Results: One hundred six patients were analyzed, and 19, 71, and 16 patients underwent conventional fractionation, hypofractionation, and hyperfractionation, respectively. The median follow-up was 56 months. The 5-year local control and overall survival rates were 79% and 83%; 78% and 79%; and 87% and 77%, respectively, and no significant difference was observed between the fractionation schedules. Conclusion: Our findings confirmed the utility of AFS in standard clinical practice and support its use for patients with EGSCC.