Social stress and the reactivation of latent herpes simplex virus type 1
Social stress and the reactivation of latent herpes simplex virus type 1
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DOI：
10.1073/pnas.95.12.7231
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发表时间：
1998-06-09
影响因子：
11.1
通讯作者：
Glaser, R
中科院分区：
文献类型：
--
作者：
Padgett, DA;Sheridan, JF;Glaser, R
心理压力被认为有助于重新激活潜伏的单纯疱疹病毒（HSV）。虽然已经开发了几种动物模型，以再现HSV角膜炎或唇疱疹的不同致病方面，但到目前为止，还没有良好的动物模型，其中应用心理实验室应激源导致病毒的可靠再活化。本文报道，小鼠群体内社会等级的破坏增加了群体间的攻击性，激活了下丘脑-垂体-肾上腺轴，并在超过40%的潜伏感染动物中引起潜伏HSV 1型的再激活。然而，激活下丘脑-垂体-肾上腺轴使用约束压力没有激活潜伏病毒。因此，在小鼠中使用社会压力提供了一个很好的模型，在其中调查的神经内分泌机制，行为介导的潜伏疱疹病毒的再激活。
Psychological stress is thought to contribute to reactivation of latent herpes simplex virus (HSV). Although several animal models have been developed in an effort to reproduce different pathogenic aspects of HSV keratitis or labialis, until now, no good animal model existed in which application of a psychological laboratory stressor results in reliable reactivation of the virus. Reported herein, disruption of the social hierarchy within colonies of mice increased aggression among cohorts, activated the hypothalamic-pituitary-adrenal axis, and caused reactivation of latent HSV type 1 in greater than 40% of latently infected animals. However, activation of the hypothalamic-pituitary-adrenal axis using restraint stress did not activate the latent virus. Thus, the use of social stress in mice provides a good model in which to investigate the neuroendocrine mechanisms that underlie behaviorally mediated reactivation of latent herpesviruses.