Studies of vascular permeability factor derived from T lymphocytes and inhibitory effect of plasma on its production in minimal change nephrotic syndrome.
Studies of vascular permeability factor derived from T lymphocytes and inhibitory effect of plasma on its production in minimal change nephrotic syndrome.
复制标题
微小病变肾病综合征中T淋巴细胞来源的血管通透因子及血浆对其产生的抑制作用的研究。
作者：
S. Tomizawa;K. Maruyama;N. Nagasawa;S. Suzuki;T. Kuroume
来自微小改变肾病综合征（MCNS）患者和对照组的外周T淋巴细胞在没有豆豆蛋白A刺激的情况下产生血管通透性因子（VPF）的能力。活性MCNS的T淋巴细胞体外培养在上清液中产生VPF，而非活性MCNS或正常受试者的T淋巴细胞则不产生VPF。此外，与非活性MCNS或胎牛血清相比，活性MCNS患者的血浆明显抑制VPF的产生。然而，活性期和非活性期的MCNS血浆对VPF活性均没有直接阻断作用。这些结果似乎表明，活跃期MCNS患者的血浆抑制VPF的产生，但不中和T淋巴细胞衍生的VPF活性。
Peripheral T lymphocytes from patients with minimal change nephrotic syndrome (MCNS) and controls were treated for their ability to produce vascular permeability factors (VPF) without concanavalin A stimulation. In vitro cultures of T lymphocytes from active MCNS produced VPF in the supernatant, whereas T lymphocytes from inactive MCNS or normal subjects did not. Furthermore, the plasma from patients with active MCNS markedly inhibited VPF production when compared with plasma taken from inactive MCNS or fetal calf serum alone. However, the plasma from MCNS in neither the active nor the inactive stage had any direct blocking effect on VPF activity. These results seem to suggest that the plasma from patients with MCNS in the active stage inhibits VPF production, but does not neutralize T lymphocytes derived VPF activity.