Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals:: Possible expansion of the role of OspE in Lyme disease pathogenesis
Selective binding of Borrelia burgdorferi OspE paralogs to factor H and serum proteins from diverse animals:: Possible expansion of the role of OspE in Lyme disease pathogenesis
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DOI：
10.1128/iai.74.3.1967-1972.2006
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发表时间：
2006-03-01
影响因子：
3.1
通讯作者：
Marconi, RT
中科院分区：
文献类型：
--
作者：
Hovis, KM;Tran, E;Marconi, RT
测定不同动物伯氏疏螺旋体OspE、OspF和家族163 （Elp）蛋白与因子H/因子H样蛋白1 （FHL-1）及其他血清蛋白的结合情况。OspF与一部分动物的结合因子H和未识别的血清蛋白相似，而OspF和Elp蛋白则不相似。这些数据促进了我们对因子H结合、莱姆病螺旋体宿主范围以及OspE在发病机制中的作用的理解。
The binding of Borrelia burgdorferi OspE, OspF, and family 163 (Elp) proteins to factor H/factor H-like protein 1 (FHL-1) and other serum proteins from different animals was assessed. OspE paralogs bound factor H and unidentified serum proteins from a subset of animals, while OspF and Elp proteins did not. These data advance our understanding of factor H binding, the host range of the Lyme spirochetes, and the expanding role of OspE in pathogenesis.