Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.
Mycobacterium tuberculosis-specific CD4 T cells expressing CD153 inversely associate with bacterial load and disease severity in human tuberculosis.
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表达 CD153 的结核分枝杆菌特异性 CD4 T 细胞与人类结核病的细菌载量和疾病严重程度呈负相关。
DOI：
10.1038/s41385-020-0322-6
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发表时间：
2021-03
影响因子：
8
通讯作者：
Riou C
中科院分区：
文献类型：
--
作者：
Du Bruyn E;Ruzive S;Lindestam Arlehamn CS;Sette A;Sher A;Barber DL;Wilkinson RJ;Riou C
最近来自小鼠和非人灵长类动物结核病模型的数据表明，CD153，TNF超家族成员，在结核分枝杆菌（Mtb）控制中起重要作用。然而，这种分子尚未在人类中进行全面评估。在这里，我们表明，Mtb特异性的CD4 T细胞表达CD153的比例显着降低活动性结核病患者相比，潜伏感染的人。重要的是，CD153+ Mtb特异性CD4应答与肺部细菌负荷呈负相关，由Xpert循环阈值推断，与HIV状态无关。抗结核治疗部分恢复了Mtb特异性CD4 T细胞上的CD153表达。这是第一次报告结核分枝杆菌特异性CD4 T细胞亚群与细菌负荷呈强负相关。基于来自动物模型的大量证据表明CD 153是宿主保护的介体，我们的研究结果表明它可能在人类中发挥类似的作用，其测量可能有助于评估TB疫苗的有效性。
Recent data from mice and non-human primate models of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in humans. Here, we show that the proportion of Mtb-specific CD4 T cells expressing CD153 was significantly reduced in active TB patients compared to latently infected persons. Importantly, the CD153+ Mtb-specific CD4 response inversely correlated with lung bacterial load, inferred by Xpert cycle threshold, irrespective of HIV status. Antitubercular treatment partially restored CD153 expression on Mtb-specific CD4 T cells. This is the first report of a subset of Mtb-specific CD4 T cells showing strong negative correlation with bacterial burden. Building on substantial evidence from animal models implicating CD153 as a mediator of host protection, our findings suggest it may play a similar role in humans and its measurement may be useful to evaluate TB vaccine efficacy.
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影响因子：
6.7
作者：
Lindestam Arlehamn CS;McKinney DM;Carpenter C;Paul S;Rozot V;Makgotlho E;Gregg Y;van Rooyen M;Ernst JD;Hatherill M;Hanekom WA;Peters B;Scriba TJ;Sette A
通讯作者：
Sette A
影响因子：
4.4
作者：
Lindenstrom, Thomas;Knudsen, Niels Peter Hell;Andersen, Peter
通讯作者：
Andersen, Peter
影响因子：
168.9
作者：
Harries, Anthony D.;Zachariah, Rony;De Cock, Kevin M.
通讯作者：
De Cock, Kevin M.
影响因子：
3.7
作者：
Card CM;Rutherford WJ;Ramdahin S;Yao X;Kimani M;Wachihi C;Kimani J;Plummer FA;Ball TB;Fowke KR
通讯作者：
Fowke KR
KLRG1 在人类 CD4 T 细胞抗结核免疫中的作用。
影响因子：
6.4
作者：
Hu, Zhidong;Zhao, Hui-Min;Fan, Xiao-Yong
通讯作者：
Fan, Xiao-Yong