Unique features of a highly pathogenic Campylobacter jejuni strain
Unique features of a highly pathogenic Campylobacter jejuni strain
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DOI：
10.1128/iai.00210-06
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发表时间：
2006-08-01
影响因子：
3.1
通讯作者：
Galan, Jorge E.
中科院分区：
文献类型：
--
作者：
Hofreuter, Dirk;Tsai, Jennifer;Galan, Jorge E.
弯曲杆菌空肠是一种主要的人类肠道病原体，表现出显着的应变对应变差异，从而导致致病潜力的差异。 C. jejuni 81-176是一种高度毒性的菌株，具有独特的致病特征，并被许多研究实验室使用。我们已经确定了其基因组的核苷酸序列，并将其与其他测序c.jejuni菌株的基因组进行了比较。我们确定了许多独特的遗传特征，这些特征可能会在该菌株上赋予特定的代谢和致病特性。我们还鉴定了jejuni基因组的区域，这些区域是整合水平获得遗传物质的热点。该信息应有助于理解空肠梭菌的发病机理，尤其是这种高度致病的菌株的独特特征。
Campylobacter jejuni, a major human enteric pathogen, exhibits significant strain-to-strain differences which result in differences in pathogenic potential. C. jejuni 81-176 is a highly virulent strain that exhibits unique pathogenic features and is used by many research laboratories. We have determined the nucleotide sequence of its genome and compared it to the genomes of other sequenced C.jejuni strains. We identified a number of unique genetic features which may confer specific metabolic and pathogenic properties on this strain. We have also identified regions of the C.jejuni genome that are hot spots for the integration of horizontally acquired genetic material. This information should help the understanding of the pathogenesis of C. jejuni and, in particular, the unique features of this highly pathogenic strain.