Binding of nuclear proteins to transcription regulatory elements in selenium deficiency.
Binding of nuclear proteins to transcription regulatory elements in selenium deficiency.
复制标题
缺硒时核蛋白与转录调控元件的结合。
DOI：
10.1016/0925-4439(94)90015-9
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Pusey,NW
中科院分区：
文献类型：
--
作者：
Christensen,MJ;Pusey,NW
饮食中缺硒的大鼠增加了肝细胞核蛋白与DNA调控序列的结合，DNA调控序列激活了转录以响应氧化应激。相反，在缺乏硒的情况下，结合到激活蛋白-1控制序列的结合减少，而激活蛋白-1控制序列被氧化抑制。
Dietary selenium deficiency in rats increased binding of liver nuclear proteins to DNA regulatory sequences which activate transcription in response to oxidative stress. In contrast, binding to the activator protein-1 control sequence, which is inhibited by oxidation, was decreased in selenium deficiency.