Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014
Emergence of Mutations in the K13 Propeller Gene of Plasmodium falciparum Isolates from Dakar, Senegal, in 2013-2014
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DOI：
10.1128/aac.01346-15
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Pradines, Bruno
中科院分区：
文献类型：
--
作者：
Boussaroque, Agathe;Fall, Becaye;Pradines, Bruno
kelch 13 (K13) 螺旋桨基因与青蒿素耐药性相关。在之前的研究中，2012 年和 2013 年从塞内加尔达喀尔居住的患者收集的 138 株恶性疟原虫分离株中没有发现突变（M. Torrentino-Madamet 等人，Malar J 13: 472, 2014， http://dx.doi.org/10.1186/1475-2875-13-472）。然而，2013 年和 2014 年，在 92 个分离株 (5.5%) 的 K13 螺旋桨区域中发现了 N554H、Q613H 和 V637I 突变。在疟原虫/Apicomplexa 特异性结构域中发现了 5 个多态性（K123R、N137S、N142NN/NNN、T149S 和K189T/N）。
The kelch 13 (K13) propeller gene is associated with artemisinin resistance. In a previous work, there were no mutations found in 138 Plasmodium falciparum isolates collected in 2012 and 2013 from patients residing in Dakar, Senegal (M. Torrentino-Madamet et al., Malar J 13: 472, 2014, http://dx.doi.org/10.1186/1475-2875-13-472). However, the N554H, Q613H, and V637I mutations were identified in the propeller region of K13 in 92 (5.5%) isolates in 2013 and 2014. There were five polymorphisms identified in the Plasmodium/Apicomplexa-specific domain (K123R, N137S, N142NN/NNN, T149S, and K189T/N).