Intracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortex.
Intracellular injection of cGMP-dependent protein kinase results in increased input resistance in neurons of the mammalian motor cortex.
复制标题
细胞内注射 cGMP 依赖性蛋白激酶会导致哺乳动物运动皮层神经元的输入阻力增加。
DOI：
10.1016/0006-8993(86)90175-7
复制
发表时间：
1986
期刊：
影响因子：
2.9
通讯作者：
Nairn,AC
中科院分区：
文献类型：
--
作者：
Woody,CD;Bartfai,T;Gruen,E;Nairn,AC
Purified, cyclic GMP-dependent protein kinase (cGPK) was pressure-injected into neurons of the precruciate cortex of awake cats. Input resistances increased within seconds after injection and remained elevated for 2 min or longer. The increases were larger when cGPK was injected in a mixture with 10 μM cGMP than when injected alone. Injections of heat-inactivated cGPK, with or without 10 the mammalian motor cortex can mimic actions of extracellularly applied acetylcholine and intracellularly applied cGMP, the latter in 100-fold higher concentrations than those used here, in neurons of the same cortical areas.
