Uveal melanoma: From diagnosis to treatment and the science in between.

Uveal melanoma: From diagnosis to treatment and the science in between.
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卵子黑色素瘤:从诊断到治疗以及两者之间的科学。

DOI:
10.1002/cncr.29727
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发表时间:
2016-08-01
期刊:
影响因子:
6.2
通讯作者:
Patel SP
Patel SP
中科院分区:
医学1区
文献类型:
--
作者:
Chattopadhyay C;Kim DW;Gombos DS;Oba J;Qin Y;Williams MD;Esmaeli B;Grimm EA;Wargo JA;Woodman SE;Patel SP

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眼睛脉络膜、睫状体和虹膜的黑色素瘤统称为葡萄膜黑色素瘤。这些癌症占美国所有黑色素瘤诊断的 5%,年龄调整后的风险为百万分之五。这些不太常见的黑色素瘤与其更常见的皮肤黑色素瘤不同,具有不同的危险因素、主要治疗、解剖学扩散、分子变化和对全身治疗的反应。一旦发生转移,治疗选择就受到限制,并且通常从皮肤黑色素瘤治疗中推断出来,尽管临床试验中常规排除了葡萄膜黑色素瘤。针对葡萄膜黑色素瘤的临床试验已经完成或正在进行中,这些精心设计的研究数据将有助于指导这种孤儿疾病的未来方向。
Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the U.S., an age-adjusted risk of 5 per million. These less frequent melanomas are dissimilar to their more common cutaneous melanoma relative, with differing risk factors, primary treatment, anatomical spread, molecular changes, and responses to systemic therapy. Once metastatic, therapy options are limited, and often extrapolated from cutaneous melanoma therapies despite routine exclusion of uveal melanoma from clinical trials. Clinical trials directed at uveal melanoma have been completed or are in progress and data from these well-designed investigations will help guide future directions in this orphan disease.
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发表时间: 2006-04-01
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