The Imaging Features and Clinical Associations of a Novel Tau PET Tracer-18F-APN1607 in Alzheimer Disease
The Imaging Features and Clinical Associations of a Novel Tau PET Tracer-18F-APN1607 in Alzheimer Disease
复制标题
DOI：
10.1097/rlu.0000000000003164
复制
发表时间：
2020-10-01
影响因子：
10.6
通讯作者：
Huang，Chin-Chang
中科院分区：
文献类型：
--
作者：
Hsu，Jung-Lung;Lin，Kun-Ju;Huang，Chin-Chang
方法应用tau蛋白示踪剂对12例正常人和10例轻、中度疑似AD患者进行检测。记录详细的临床信息、认知测量和疾病严重程度。18架F-AV-45的区域SUV比率结果定量分析显示，在额叶、颞叶、顶叶、枕叶、前扣带回和后扣带回、楔前叶，海马旁区（P均< 0.01），效应量为0.44-0.75。18F-APN 1607 PET显像的SUVR与阿尔茨海默病评估量表（ADAS-cog）评分显著相关（P均< 0.01），相关系数（R2范围为0.54 ~ 0.68），甚至校正了年龄和性别效应。最后，海马旁区18 F-APN 1607 PET成像的SUVR随着ADAS-cog评分的增加而迅速饱和，扣带回后部以及颞、额、顶和枕区的SUVR缓慢增加。从淀粉样蛋白，tau PET，和区域GM萎缩率的组合SUVR显示区域特定的模式作为ADAS-cog scoresincreased.ConclusionsOur的研究结果表明，18 F-APN 1607 tau示踪剂与认知变化相关，并表现出空间模式的淀粉样蛋白，tau沉积，和GM萎缩在AD的进展。
MethodsWe applied tau tracer in 12 normal controls (NCs) and 10 patients in the mild to moderate stage of probable AD. Detailed clinical information, cognitive measurements, and disease severity were documented. Regional SUV ratios (SUVRs) from 18 F-AV-45 (florbetapir), 18 F-APN1607 PET images, and regional gray matter (GM) atrophic ratios were calculated for further analysis.ResultsQuantitative analyses showed significantly elevated SUVRs in the frontal, temporal, parietal, occipital lobes, anterior and posterior cingulate gyri, precuneus, and parahippocampal region (all P’s< 0.01) with medium to large effect sizes (0.44–0.75). The SUVRs from 18 F-APN1607 PET imaging showed significant correlations with the Alzheimer’s Disease Assessment Scale (ADAS-cog) scores (all P’s< 0.01) and strong correlation coefficients (R 2 ranged from 0.54 to 0.68), even adjusted for age and sex effects. Finally, the SUVRs from 18 F-APN1607 PET imaging of the parahippocampal region showed rapid saturation as the ADAS-cog scores increased, and the SUVRs of the posterior cingulate gyrus and the temporal, frontal, parietal, and occipital regions slowly increased. The combined SUVRs from amyloid, tau PET, and regional GM atrophic ratio showed regional specific patterns as the ADAS-cog scores increased.ConclusionsOur findings suggest that the 18 F-APN1607 tau tracer correlated well with cognitive changes and demonstrated the spatial pattern of amyloid, tau deposition, and GM atrophy in the progression of AD.