Spectrum of Slow and Super-Slow (Picosecond to Nanosecond) Water Dynamics around Organic and Biological Solutes.
Spectrum of Slow and Super-Slow (Picosecond to Nanosecond) Water Dynamics around Organic and Biological Solutes.
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DOI：
10.1021/acs.jpclett.7b01127
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发表时间：
2017-06
期刊：
影响因子：
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通讯作者：
G. Ramakrishnan;Mario González-Jiménez;A. Lapthorn;K. Wynne
中科院分区：
文献类型：
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作者：
G. Ramakrishnan;Mario González-Jiménez;A. Lapthorn;K. Wynne
溶质溶剂化壳层中的水动力学在生物分子相互作用和化学反应动力学中起着非常重要的作用。然而，溶剂化壳层的选择性光谱研究是困难的，因为溶质动力学的干扰。在这里，我们报告的观察严重减缓水动力学在不同溶质的溶剂化壳层通过测量溶剂化水的低频光谱，从溶质的贡献。即使对于相对较低浓度的溶质，也观察到1.50的减速因子。我们继续表明，该效果可以推广到不同的溶质，包括蛋白质。
Water dynamics in the solvation shell of solutes plays a very important role in the interaction of biomolecules and in chemical reaction dynamics. However, a selective spectroscopic study of the solvation shell is difficult because of the interference of the solute dynamics. Here we report on the observation of heavily slowed down water dynamics in the solvation shell of different solutes by measuring the low-frequency spectrum of solvation water, free from the contribution of the solute. A slowdown factor of ∼50 is observed even for relatively low concentrations of the solute. We go on to show that the effect can be generalized to different solutes including proteins.