Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors.
Brief optogenetic inhibition of dopamine neurons mimics endogenous negative reward prediction errors.
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DOI：
10.1038/nn.4191
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发表时间：
2016-01
影响因子：
25
通讯作者：
Schoenbaum G
中科院分区：
文献类型：
--
作者：
Chang CY;Esber GR;Marrero-Garcia Y;Yau HJ;Bonci A;Schoenbaum G
相关研究表明多巴胺活性的阶段性变化与奖励预测误差信号密切相关。但关于放电的这些短暂变化实际上充当驱动联想学习的错误信号的因果证据则更加脆弱。虽然有直接证据表明短暂的增加可以替代正预测误差，但没有类似的证据表明类似的短暂停顿可以替代负预测误差。由于缺乏此类证据，放电增加的影响可能反映出新颖性或显着性，这些变量也与多巴胺活动相关。在这里，我们提供了这样的证据，表明在改良的巴甫洛夫过度期望任务中，奖励时大鼠腹侧被盖区多巴胺神经元放电的短暂暂停足以模拟内源性负预测误差的影响。这些结果支持这样的观点：多巴胺神经元放电的短暂变化可以作为成熟的双向预测误差信号。
Correlative studies have strongly linked phasic changes in dopamine activity with reward prediction error signaling. But causal evidence that these brief changes in firing actually serve as error signals to drive associative learning is more tenuous. While there is direct evidence that brief increases can substitute for positive prediction errors, there is no comparable evidence that similarly brief pauses can substitute for negative prediction errors. Lacking such evidence, the effect of increases in firing could reflect novelty or salience, variables also correlated with dopamine activity. Here we provide such evidence, showing in a modified Pavlovian over-expectation task that brief pauses in the firing of dopamine neurons in rat ventral tegmental area at the time of reward are sufficient to mimic the effects of endogenous negative prediction errors. These results support the proposal that brief changes in the firing of dopamine neurons serve as full-fledged bidirectional prediction error signals.