DNA repair in Mycobacterium tuberculosis.: What have we learnt from the genome sequence?
DNA repair in Mycobacterium tuberculosis.: What have we learnt from the genome sequence?
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DOI：
10.1046/j.1365-2958.1998.01038.x
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发表时间：
1998-09-01
影响因子：
3.6
通讯作者：
Andersen, SJ
中科院分区：
文献类型：
--
作者：
Mizrahi, V;Andersen, SJ
通过寻找已知参与大肠杆菌和相关生物体中DNA损伤逆转或修复的基因的同源物，分析了结核分枝杆菌的基因组序列。鉴定了进行核苷酸切除修复（NER）、碱基切除修复（BER）、重组和SOS修复和诱变所必需的基因。特别是，所有已知直接参与氧化和烷基化损伤修复的基因都存在于M。结核相比之下，我们未能确定参与错配修复的基因的同源物。这一发现对基因组稳定性、重复位点的菌株变异性和染色体编码的耐药突变的出现具有潜在的重要意义。
The genome sequence of Mycobacterium tuberculosis was analysed by searching for homologues of genes known to be involved in the reversal or repair of DNA damage in Escherichia coli and related organisms. Genes necessary to perform nucleotide excision repair (NER), base excision repair (BER), recombination, and SOS repair and mutagenesis were identified. In particular, all of the genes known to be directly involved in the repair of oxidative and alkylative damage are present in M. tuberculosis. In contrast, we failed to identify homologues of genes involved in mismatch repair. This finding has potentially significant implications with respect to genome stability, strain variability at repeat loci and the emergence of chromosomally encoded drug resistance mutations.